Description
Cagrilintide (5mg) | Long-Acting Amylin Analogue — Metabolic Research
Cagrilintide is a fatty-acid-conjugated, long-acting analogue of amylin (IAPP — islet amyloid polypeptide), developed by Novo Nordisk. Amylin is co-secreted with insulin from pancreatic beta cells and acts as a satiety hormone through central and peripheral mechanisms. When combined with semaglutide (the CagriSema combination in Phase III), it demonstrated ~25% weight loss — exceeding either agent alone, suggesting additive receptor pathway utilisation.
Mechanism of Action
- Amylin receptor agonism — activates CTR/RAMP complexes (AMY1, AMY2, AMY3) in the area postrema and nucleus accumbens, reducing food intake
- Gastric emptying delay — slows gastric transit via vagal and CNS pathways, complementary to and additive with GLP-1R-mediated delay
- Glucagon suppression — attenuates post-prandial glucagon secretion independently of insulin
- Satiety signaling — acts on hypothalamic satiety circuits via distinct pathways from GLP-1 agonists, enabling combination effects
Research Areas
Cagrilintide is studied in obesity, combination metabolic therapy, and amylin biology research. Its orthogonal receptor mechanism makes it particularly relevant in combination studies with Retatrutide and Tirzepatide for understanding multi-receptor weight loss pharmacology.
For Research Use Only. Rainbow Peptide supplies this compound exclusively for in vitro and laboratory research purposes. Not for human or veterinary use.
Dr. N. Svensson –
Cagrilintide is our primary amylin analogue for our satiety axis research. Rainbow Peptide’s 5mg vial had >98.5% purity confirmed by LC-MS. Receptor binding profile matched published data precisely. Excellent COA documentation.
T. Williams –
Very impressed with the Cagrilintide quality. Hard peptide to source at this purity level. Mass spec confirmed sequence integrity. Cold pack was still frozen on arrival. COA detailed endotoxin and residual solvent levels too.
J. Dlamini –
Cagrilintide performed well in our amylin receptor assay. Purity >98% independently verified. Dissolved cleanly. COA was thorough. Will continue sourcing from Rainbow Peptide for our obesity model research.