5-Amino-1MQ

Description

5-Amino-1MQ | NNMT Inhibitor, Research Grade

5-Amino-1MQ (5-Amino-1-methylquinolinium) is a cell-permeable small molecule and potent inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme highly expressed in white adipose tissue. Preclinical studies have reported significant fat mass reduction, increased energy expenditure, and enhanced NAD+ metabolite levels.

Mechanism of Action

• NNMT inhibition, blocks methylation of nicotinamide, redirecting methyl groups and increasing SAM (S-adenosylmethionine) availability
• NAD+ precursor pool expansion, reduces consumption of NAD+ precursors, boosting cellular NAD+ levels
• Adipocyte differentiation suppression, inhibits pre-adipocyte differentiation into mature fat cells in vitro
• No appetite suppression, preclinical data suggests fat reduction without orexigenic pathway involvement

Research Areas

5-Amino-1MQ is studied in obesity, adipose metabolism, NAD+ biology, and longevity research. It represents a mechanistically distinct approach to fat metabolism compared to GLP-1 or GH-based compounds.

Independent Lab Verification

This compound has been independently tested by Vanguard Laboratory, an ISO 17025:2017-accredited third-party laboratory (A2LA Certificate #6377.01.01), confirming a chromatographic purity of ≥99.80% via HPLC-UV/VIS analysis. This identity and purity data is what verifies the compound matches its labeled specification, not just a claim we make ourselves.

For Research Use Only. Rainbow Peptide supplies 5-Amino-1MQ exclusively for in vitro and laboratory research purposes. Not for human or veterinary use.