Description
AICAR | AMPK Activator, Research Grade
AICAR (5-Aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside) is a nucleoside analogue that is phosphorylated intracellularly to ZMP, an AMP mimetic that activates AMP-activated protein kinase (AMPK). It is one of the most widely used pharmacological AMPK activators in metabolic research.
Mechanism of Action
- AMPK activation, ZMP (intracellular product) mimics AMP, activating AMPK via allosteric binding and prevention of dephosphorylation
- Fatty acid oxidation, AMPK-mediated phosphorylation of ACC reduces malonyl-CoA, increasing mitochondrial fatty acid entry
- Glucose uptake, promotes GLUT4 translocation in skeletal muscle independent of insulin
- PGC-1alpha induction, drives mitochondrial biogenesis via PGC-1alpha, the master regulator of oxidative metabolism
Research Areas
AICAR is studied in metabolic syndrome, type 2 diabetes, exercise physiology, skeletal muscle adaptation, and longevity biology. It is frequently used alongside MOTS-c as an exercise-mimetic research tool.
Independent Lab Verification
Rainbow Peptide works with independent, accredited third-party laboratories, including Vanguard Laboratory (ISO 17025:2017-accredited, A2LA Certificate #6377.01.01), to verify compound identity and purity. A Certificate of Analysis is included with every order.
For Research Use Only. Rainbow Peptide supplies AICAR exclusively for in vitro and laboratory research purposes. Not for human or veterinary use.
Dr. L. Schreiber –
AICAR for our AMPK activation and exercise mimetic research. Purity >99% confirmed by HPLC. AMPK phosphorylation assay in our muscle cell model showed robust dose-dependent response. COA excellent.
C. Magnusson –
Consistent quality AICAR. Our mitochondrial biogenesis research program relies on this compound. Purity confirmed >98.5% each lot. COA includes full HPLC trace. Fast shipping, good documentation.
T. Adebayo –
AICAR dissolved easily in PBS. Purity >98%. Our glucose uptake assay in L6 myotubes showed the expected AMPK-mediated response. COA detailed. Good packaging and delivery.