Description
MOTS-c | Mitochondria-Derived Metabolic Peptide — Research Grade
MOTS-c is a 16-amino acid peptide encoded within the mitochondrial 12S rRNA gene (MT-RNR1), making it one of the few mitochondria-derived peptides (MDPs) identified in humans. It translocates to the nucleus during metabolic stress and directly modulates gene expression related to glucose homeostasis.
Mechanism of Action
- AMPK activation — activates AMP-activated protein kinase, the master metabolic switch governing glucose uptake and fatty acid oxidation
- Folate cycle modulation — inhibits the folate cycle and de novo purine synthesis, triggering AICAR accumulation and downstream AMPK signalling
- Exercise-mimicking — plasma levels increase with physical exercise; supplementation mimics exercise-like metabolic adaptations in rodent models
- Insulin sensitisation — improves insulin sensitivity in high-fat diet and diabetic rodent models
Research Areas
MOTS-c is studied in type 2 diabetes, obesity, exercise physiology, skeletal muscle metabolism, and longevity/ageing biology. Circulating MOTS-c levels decline with age, making it a candidate for ageing research interventions.
For Research Use Only. Rainbow Peptide supplies MOTS-c exclusively for in vitro and laboratory research purposes. Not for human or veterinary use.
Dr. J. Lee –
MOTS-c for our mitochondria-encoded peptide and AMPK activation research. Purity confirmed at 98.8% by HPLC. AMPK phosphorylation response in our muscle cell model matched published data. COA was the most detailed we’ve received.
H. Kim –
MOTS-c is a challenging peptide to source at high purity. Rainbow Peptide delivered 98.6% confirmed by our independent LC-MS. Our exercise mimetic research panel relies on this supplier. Fast shipping, excellent packaging.
L. Okafor –
MOTS-c for our longevity peptide panel. Purity above 98%, dissolved cleanly. COA confirmed molecular weight and sequence. In our glucose metabolism model, response was as expected from the literature.