Description
AOD-9604 | HGH Fragment 176-191 — Research Grade
AOD-9604 is a 16-amino acid peptide corresponding to residues 176-191 of human growth hormone, featuring a stabilising disulfide bridge between Cys182 and Cys189. It has received FDA GRAS (Generally Recognised As Safe) status and has been evaluated in Phase II clinical trials for obesity.
Mechanism of Action
- Beta-3 adrenergic stimulation — activates beta-3 adrenergic receptors in adipocytes, triggering lipolysis independent of GHR
- Anti-lipogenic action — inhibits acetyl-CoA carboxylase (ACC), reducing de novo lipogenesis
- No GHR/IGF-1 activation — does not bind the GH receptor or elevate insulin or IGF-1 levels
- Chondroprotective — studied in Phase IIa OA trials for cartilage repair properties
Research Areas
AOD-9604 has been studied in obesity (Phase II RCT: -1.4 kg fat mass vs +0.5 kg placebo, 12 weeks), osteoarthritis, and cartilage repair. Its separation of lipolytic from growth-promoting effects makes it a useful research tool in metabolic biology.
For Research Use Only. Rainbow Peptide supplies AOD-9604 exclusively for in vitro and laboratory research purposes. Not for human or veterinary use.
B. Stanton –
AOD-9604 arrived quickly and in excellent condition. Cold pack still active. Purity verified at >98% by our HPLC. Results in our metabolic rate assay consistent with published parameters. COA was thorough. Will reorder.
Dr. V. Novak –
AOD-9604 for our adipogenesis inhibition research. Purity confirmed 98.7%. The peptide showed expected activity in our pre-adipocyte differentiation assay. COA was detailed and included residual solvent data.
L. Achebe –
Good quality AOD-9604. Purity >98%. Dissolved cleanly. Our lipolysis model showed dose-dependent response consistent with peer-reviewed literature. COA comprehensive. Fast processing and delivery.