Description
Enclomiphene Powder — Research Overview
Enclomiphene is the trans-isomer of clomiphene citrate (the active isomeric component), a non-steroidal selective estrogen receptor modulator (SERM) studied for testosterone restoration via HPTA axis modulation. Unlike clomiphene citrate (a 62:38 mixture of zuclomiphene:enclomiphene), enclomiphene as an isolated isomer has distinct pharmacokinetics and a cleaner estrogen receptor antagonism profile relevant for gonadotropin research.
Mechanism of Action
Enclomiphene acts as an estrogen receptor antagonist in the hypothalamus and pituitary gland, blocking the negative feedback of estradiol on GnRH and LH/FSH secretion. This disinhibition of the HPTA axis increases LH and FSH pulse amplitude and frequency, driving endogenous testicular testosterone production. Unlike exogenous testosterone, enclomiphene preserves spermatogenesis — a key distinction for male reproductive endocrinology research.
HPTA Research Applications
Enclomiphene is used in: hypogonadism mechanism research, HPTA axis recovery modelling (post-exogenous androgen suppression), male fertility and spermatogenesis studies, and estrogen receptor pharmacology in CNS and reproductive tissue. Phase II/III clinical data (Wiehle et al., 2014) demonstrated normalisation of testosterone in secondary hypogonadal men with preserved sperm parameters — providing a validated human reference dataset.
Isomeric Purity vs Clomiphene Citrate
Research using isolated enclomiphene (vs. racemic clomiphene) enables cleaner mechanistic data by eliminating confounding effects of zuclomiphene, which has longer half-life and partial ER agonist activity. This makes enclomiphene powder the preferred tool compound for SERM receptor selectivity studies.
Powder Format for Research
Soluble in DMSO (≥50mg/mL) and ethanol. For in vitro ER antagonism assays, cell-free receptor binding, and in vivo rodent HPTA studies. Standard rodent dosing: 1–10mg/kg/day oral.
Purity: ≥98% (HPLC verified) | Format: Lyophilised powder | Quantity: 1g
For research use only. Not for human consumption.
Dr. M. Sigman –
Enclomiphene bulk powder for high-volume SERM research. Chiral purity confirmed >98% trans-isomer by our chiral HPLC. COA detailed. Our HPT axis research panel uses this bulk format.
B. Eriksson –
1g Enclomiphene powder — excellent for bulk estrogen receptor research. Isomeric purity confirmed. COA thorough. Fast delivery. Our LH/FSH model showed consistent results.
T. Okafor –
Good bulk Enclomiphene powder. Chiral purity >98% trans-isomer. Dissolved cleanly. COA comprehensive. Practical for high-volume SERM research.