Description
YK-11 Research Chemical
YK-11 is a unique steroidal SARM first described by Kanno et al. (2011) at Tokai University. Unlike non-steroidal SARMs (RAD-140, LGD-4033, Ostarine), YK-11 has a steroidal scaffold structurally similar to DHT (dihydrotestosterone). It is studied for a dual mechanism: partial AR agonism, plus induction of follistatin expression in myocytes, leading to reduced myostatin activity.
Research Applications
- Myostatin inhibition: YK-11 induces follistatin (FST) in C2C12 myoblasts — unique among SARMs
- Muscle hypertrophy signalling research — mTOR/Akt/follistatin pathway
- Partial vs full AR agonism comparative studies
- Steroidal vs non-steroidal SARM mechanistic comparison
Research Notes
YK-11 has a steroidal backbone — researchers should note potential for oestrogenic metabolites (aromatization possible but not well characterized). Limited in vivo rodent data vs non-steroidal SARMs. Primarily studied in cell culture.
Product Specifications
- Purity: ≥98% HPLC confirmed
- Identity: Mass spectrometry (MW: 430.54)
- CoA: Third-party laboratory
- Form: Lyophilized powder, sealed vial
For Research Use Only (RUO). Not for human consumption.
