Description
1-MNA Capsules | 1-Methylnicotinamide — NAD⁺ Metabolite Research
1-MNA (1-Methylnicotinamide chloride; NMN-Cl) is a naturally occurring metabolite of nicotinamide produced by the enzyme NNMT (nicotinamide N-methyltransferase). Once considered an inert urinary excretion product, recent research has established 1-MNA as a bioactive signaling molecule with anti-inflammatory, antioxidant, anti-thrombotic, and SIRT1-stabilising activities. These capsules (60mg per capsule, 60 capsules) provide a convenient oral research format.
Mechanism of Action
- SIRT1 stabilisation — reduces proteasomal degradation of SIRT1 protein in hepatocytes, increasing SIRT1 activity and downstream metabolic regulation
- NF-κB inhibition — prevents p65 nuclear translocation; inhibits TNF-α, IL-6, and IL-1β production
- Myokine activity — secreted by skeletal muscle during exercise to stimulate adipose tissue lipolysis and coordinate systemic energy use
- Prostacyclin pathway — exerts COX-2/prostacyclin-mediated anti-thrombotic and endothelial-protective effects
Research Areas
1-MNA capsules are studied in NAD+ biology, cardiometabolic research, NNMT pathway studies, and exercise physiology. Closely related to 5-Amino-1MQ capsules (direct NNMT inhibitor) for comparative NNMT pathway research.
For Research Use Only. Rainbow Peptide supplies this compound exclusively for in vitro and laboratory research purposes. Not for human or veterinary use.
Dr. A. Szczeklik –
1-MNA capsules for our NAD+ precursor and anti-inflammatory research. Purity confirmed >99% by HPLC. SIRT1 pathway assay showed expected activity. COA detailed. The 60mg dose per capsule was accurate within ±2% of label claim.
P. Wojtyla –
60mg 1-Methylnicotinamide capsules — ideal for our anti-thrombotic and vasodilatory research model. Content confirmed. COA thorough. Our prostacyclin pathway assay showed expected 1-MNA activity.
T. Nwosu –
Good 1-MNA capsules. Content >98.5%. Capsule uniformity within spec. COA comprehensive. Convenient oral format for NAD+ metabolism and tryptophan pathway research.